This research proposes a national architecture and building blocks framework which can be implemented by water and wastewater utilities to improve their operations at the watershed or sewershed scale. The proposed intelligent water system framework is tilted as “Intelligent Water Infrastructure Systems Engineering (iWISE). Utilities need to manage assets, analyze data, and make data-driven decisions. iWISE framework will empower utilities to do this with a modern data model, out-of-the-box analytics tools, and step-by-step iWISE implementation plan. It will support digital twins and artificial intelligence applications, provide data guidance, and make sharing data across the enterprise easy.